Article:Induction of specific immune tolerance with hybrid antibodies

Authors:Staerz, U.D., Lee, D.S., Qi, Yan

Journal:Immunology Today April 2000, volume 21, no. 4, pp. 172-175

Abstract:The veto effect has been shown to inhibit T cells efficiently and specifically.However, since CD8+ T cells are used as the tolerizing veto cells, this strategy cannot provide complete tolerance to a transplanted organ nor remove pathogenic T cells of an autoimmune disease.Here Uwe Staerz and colleagues review hybrid antibody-mediated inhibition of T cells that exploits the effectiveness and specificity of veto, yet broadens its reach to tissue-specific T cells.